What is it?
Shiitake mushroom (Lentinus edodes) is a type of edible fungus. It’s native to Japan and China, and contains a chemical called lentinan.
Shiitake mushrooms are the second most commonly eaten mushrooms in the world. Lentinan and other chemicals in shiitake mushrooms might stimulate the immune system.
People use shiitake mushroom or an extract called AHCC for HIV/AIDS, common cold, flu, and many other conditions, but there is no good scientific evidence to support these uses. There is also no good evidence to support using shiitake mushroom for COVID-19.
Is it effective?
NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Possibly Ineffective for …
- Tooth plaque. Rinsing the mouth with a liquid containing shiitake mushroom doesn’t seem to reduce tooth plaque.
There is interest in using shiitake mushroom for a number of other purposes, but there isn’t enough reliable information to say whether it might be helpful.
Is there concern for the safety of its use?
When taken by mouth: Shiitake mushroom is likely safe when cooked and eaten in food amounts. A specific extract called AHCC is possibly safe in doses ranging from 4.5 to 6 grams daily for up to 6 months or doses of 3 grams daily for up to 9 years. Shiitake mushroom is possibly unsafe when used in larger amounts as medicine, or when the uncooked mushroom is eaten. It can cause stomach discomfort, blood abnormalities, and skin swelling. It might also make the skin more sensitive to the sun and can cause allergic skin reactions and breathing problems in some people.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn’t enough reliable information to know if shiitake mushroom is safe to use when pregnant or breast-feeding. Stay on the safe side and stick to food amounts.
“Auto-immune diseases” such as multiple sclerosis (MS), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), or other conditions: Shiitake mushroom might cause the immune system to become more active. This could increase the symptoms of auto-immune diseases. If you have one of these conditions, it’s best to avoid using shiitake mushroom.
A blood disorder called hypereosinophilic syndrome: Don’t use shiitake mushroom if you have this condition. It might make it worse.
Are there any drug interactions?
Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. Shiitake mushroom might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications that decrease the immune system (Immunosuppressants)
Interaction Rating=Moderate Be cautious with this combination.
Shiitake mushroom can increase the activity of the immune system. Some medications, such as those used after a transplant, decrease the activity of the immune system. Taking shiitake mushroom along with these medications might decrease the effects of these medications.
Are there any interactions with herbs and supplements?
There are no known interactions with herbs and supplements.
Are there any interactions with food?
There are no known interactions with foods.
What dose is used?
There isn’t enough reliable information to know what an appropriate dose of shiitake mushroom might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.
By what other names is the product known?
Active hexose correlated compound, AHCC, Champignon Noir, Champignon Parfumé, Champignon Shiitake, Champignons Shiitake, Composé Corrélé d’Hexose Actif, Compuestos Activos Correlacionados Hexosa, Forest Mushroom, Hongos Shiitake, Hua Gu, Lenticus edodes, Lentin, Lentin des Chênes, Lentin du Chêne, Lentinan edodes, Lentinula, Lentinula edodes, Lentinus edodes, Mushroom, Pasania Fungus, sh*take, Shiitake, Snake Butter, Tricholomopsis edodes, Xiang Gu.
Information on this website is for informational use only and is not intended to replace professional medical advice, diagnosis, or treatment. While evidence-based, it is not guaranteed to be error-free and is not intended to meet any particular user’s needs or requirements or to cover all possible uses, safety concerns, interactions, outcomes, or adverse effects. Always check with your doctor or other medical professional before making healthcare decisions (including taking any medication) and do not delay or disregard seeking medical advice or treatment based on any information displayed on this website.
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