Shiitake Mushroom - Susan G. Komen® (2024)

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What is it?

Shiitake mushroom (Lentinus edodes) is a type of edible fungus. It’s native to Japan and China, and contains a chemical called lentinan.

Shiitake mushrooms are the second most commonly eaten mushrooms in the world. Lentinan and other chemicals in shiitake mushrooms might stimulate the immune system.

People use shiitake mushroom or an extract called AHCC for HIV/AIDS, common cold, flu, and many other conditions, but there is no good scientific evidence to support these uses. There is also no good evidence to support using shiitake mushroom for COVID-19.

Is it effective?

NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

Possibly Ineffective for …

  • Tooth plaque. Rinsing the mouth with a liquid containing shiitake mushroom doesn’t seem to reduce tooth plaque.

There is interest in using shiitake mushroom for a number of other purposes, but there isn’t enough reliable information to say whether it might be helpful.

Is there concern for the safety of its use?

When taken by mouth: Shiitake mushroom is likely safe when cooked and eaten in food amounts. A specific extract called AHCC is possibly safe in doses ranging from 4.5 to 6 grams daily for up to 6 months or doses of 3 grams daily for up to 9 years. Shiitake mushroom is possibly unsafe when used in larger amounts as medicine, or when the uncooked mushroom is eaten. It can cause stomach discomfort, blood abnormalities, and skin swelling. It might also make the skin more sensitive to the sun and can cause allergic skin reactions and breathing problems in some people.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn’t enough reliable information to know if shiitake mushroom is safe to use when pregnant or breast-feeding. Stay on the safe side and stick to food amounts.

“Auto-immune diseases” such as multiple sclerosis (MS), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), or other conditions: Shiitake mushroom might cause the immune system to become more active. This could increase the symptoms of auto-immune diseases. If you have one of these conditions, it’s best to avoid using shiitake mushroom.

A blood disorder called hypereosinophilic syndrome: Don’t use shiitake mushroom if you have this condition. It might make it worse.

Are there any drug interactions?

Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates)

Interaction Rating=Moderate Be cautious with this combination.

Some medications are changed and broken down by the liver. Shiitake mushroom might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

Medications that decrease the immune system (Immunosuppressants)

Interaction Rating=Moderate Be cautious with this combination.

Shiitake mushroom can increase the activity of the immune system. Some medications, such as those used after a transplant, decrease the activity of the immune system. Taking shiitake mushroom along with these medications might decrease the effects of these medications.

Are there any interactions with herbs and supplements?

There are no known interactions with herbs and supplements.

Are there any interactions with food?

There are no known interactions with foods.

What dose is used?

There isn’t enough reliable information to know what an appropriate dose of shiitake mushroom might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.

By what other names is the product known?

Active hexose correlated compound, AHCC, Champignon Noir, Champignon Parfumé, Champignon Shiitake, Champignons Shiitake, Composé Corrélé d’Hexose Actif, Compuestos Activos Correlacionados Hexosa, Forest Mushroom, Hongos Shiitake, Hua Gu, Lenticus edodes, Lentin, Lentin des Chênes, Lentin du Chêne, Lentinan edodes, Lentinula, Lentinula edodes, Lentinus edodes, Mushroom, Pasania Fungus, sh*take, Shiitake, Snake Butter, Tricholomopsis edodes, Xiang Gu.

Information on this website is for informational use only and is not intended to replace professional medical advice, diagnosis, or treatment. While evidence-based, it is not guaranteed to be error-free and is not intended to meet any particular user’s needs or requirements or to cover all possible uses, safety concerns, interactions, outcomes, or adverse effects. Always check with your doctor or other medical professional before making healthcare decisions (including taking any medication) and do not delay or disregard seeking medical advice or treatment based on any information displayed on this website.

© TRC Healthcare 2024. All rights reserved. Use and/or distribution is permitted only pursuant to a valid license or other permission from TRC Healthcare.

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Shiitake Mushroom - Susan G. Komen® (2024)

FAQs

What does shiitake mushroom do for your body? ›

Shiitake are rich in polysaccharides like lentinans and other beta-glucans. These compounds protect against cell damage, help your immune system, and boost white blood cell production for fighting off microbes. Polysaccharides also have anti-inflammatory properties.

Is shiitake mushroom against cancer? ›

One shiitake extract called lentinan is a beta glucan. This is a type of complex sugar compound. Beta glucan may stimulate the immune system. It may do this by triggering certain cells and proteins in the body to attack cancer cells.

How to know if sh*take mushroom is bad? ›

How to tell if shiitake mushrooms are bad. Shiitake mushrooms can go bad quickly, so it's important to check them before cooking. Throw the mushrooms if they are slimy or the underside of the caps are darker than when you bought them. If you notice any brown or dark spots, then it means the mushrooms are decaying.

Is any part of a shiitake mushroom poisonous? ›

Shiitake mushrooms do not make toxins. However, parasitic fungi present on the mushrooms may be toxic. The mushrooms, which grow on oak logs, are low in calories but high in minerals such as potassium and zinc. Shiitake mushrooms, unlike some mushroom varieties, are not poisonous.

Why don't you eat shiitake stems? ›

Shiitake Stems: The Woody Dilemma

These stems are notoriously woody and tough to chew. For an enjoyable culinary adventure, it's best to remove the shiitake stems before cooking. But don't toss it away! It can be popped into the freezer and saved to make a delicious mushroom stock!

What is the healthiest mushroom? ›

Some of the mushrooms considered best for human health include chaga, lion's mane, reishi, turkey tail, shiitake, cordyceps and maitake. Often considered vegetables, mushrooms are neither plants nor animals. They belong to a unique kingdom of fungi.

Who should not take shiitake? ›

Stay on the safe side and avoid use. “Auto-immune diseases” such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other conditions: Shiitake mushroom might cause the immune system to become more active.

Is shiitake a medicinal mushroom? ›

Shiitake (Lentinus edodes) is a culinary-medicinal mushroom that has low lipid content and is rich in protein, fiber, minerals, vitamins, antioxidant compounds, and β-glucans.

What is mushroom like cancer? ›

Fungating describes what the cancer might look like. They can grow in the shape of a fungus or cauliflower. As the cancer grows, it blocks and damages small blood vessels. This reduces the oxygen supply to the area.

What does bad shiitake smell like? ›

Sour or fishy smell Fresh mushrooms should smell slightly sweet and earthy, but not foul. If you give them a whiff and they smell fishy or pungent, it's time to toss them. This means that the mushrooms are too far gone to eat.

What does a good shiitake mushroom look like? ›

At the grocery store, select shiitake mushrooms that are firm with a fresh, smooth appearance. The surface of the mushroom should be dry, but not dried out, and appear plump. Gills should appear firm.

Why is my shiitake mushroom bitter? ›

Guanylate, an Umami component unique to dried Shiitake, gives a bitter taste if its concentration is too high. You can simply dilute it to solve the problem. More information about natural Umami.

What is the most poisonous mushroom in the world? ›

Amanita phalloides is the most poisonous of all known mushrooms. It is estimated that as little as half a mushroom contains enough toxin to kill an adult human.

How long does shiitake mushroom poisoning last? ›

Affected individuals should avoid consuming undercooked shiitake mushrooms in the future. The rash typically occurs 2‐5 days after consuming shiitake mushrooms and spontaneously resolves after 10‐14 days with conservative management; however, antihistamines and topical or oral corticosteroids are often also used.

Is Shiitake mushroom good for weight loss? ›

Studies have reported that b-glucan can increase satiety, reduce food intake, delay nutrition absorption and reduce plasma lipid (fat) levels. The researchers concluded by suggesting that shiitake mushrooms can help prevent body weight gain, fat deposition and plasma triacylglycerol when added to a high-fat diet.

What does shiitake do for hair? ›

Hair Specialty: To improve hair resilience - Shiitake mushroom extract is known to strengthen and protect your hair from external factors such as environmental stressors, chemical treatments, and daily wear and tear.

Is shiitake good for brain? ›

Shiitake: Shiitake mushroom contains compounds that can improve cognitive function and protect the brain from damage.

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